Things You Should Know About Fenbendazole

Fenbendazole

Frequently called Fenben or Panacur, is a benzimidazole class anthelmintic medication. It’s been in use worldwide since its discovery in 1974. (Ref.) During the last few decades it’s been observed that fenbendazole as well as comparable drugs demonstrated a significant anti-cancer impact. (Ref.1, Ref.2)

That brought theories that this listed de-wormer for dogs may be reused as corresponding anti-cancer medication. Actually, benzimidazole class drugs may perform similarly as a broad range of contemporary chemotherapeutic medications like Taxol and vinca alkaloids. (Ref.) The accessible toxicological data indicates that fenbendazole appears to be well accepted in people after oral contact, though there are few studies with humans. (Ref.)

Under typical circumstances, unadulterated fenbendazole is available in a powder format, and is a whitish hue with weak water solubility.

This drug has a low reabsorption in the bowels. Bioavailability may be enhanced by the existence of food in the stomach.

How does fenbendazole work?

Fenbendazole was initially intended to treat parasites by selectively impeding the production of microtubules via fastening to β-tubulin. That prevents the polymerization of tubulin dimers in parasite cells and brings on their death.

Amazingly, it appears fenbendazole along with other types of benzimidazoles shows a comparable effect when pitted against tumor cells. At present it’s believed there are three key methods in how fenbendazole destroys cancer cells:

1) Apoptosis induction. This anti-tumor effect is thought to be done via a collaboration of the medicine with the β-tubulin, which leads to stopping the cell cycle along with being cytotoxic.

Stopping tubulin polymerization into microtubules via benzimidazole carbamates in the helminths as well as in human tumor cells has been well verified. (Ref.1, Ref.2)

2) Stoppage of glucose usage in cancer cells. Cancer cells are well-known for having an immense uptake of glucose. Cancer cells typically use glucose two hundred times quicker than normal cells because of aerobic glycolysis (the Warburg effect). That is revealed in PET scans – the metabolically functional sites, that use additional radioactive glucose is clearly observed and usually believed to be inflammation or cancerous tumors.

Fenbendazole restricts cancer cell feeding with sugar via restricting the uptake of glucose, reducing the quantity of GLUT transporters (channels that bring glucose into the cancerous cells from the blood) as well as the enzyme Hexokinase II. Hexokinase II is crucial for the survival of cancer cells. It supports the tumours and helps them thrive via producing additional sugar and speeding up lactic acidosis inside the extracellular matrix. (Ref.1, Ref.2)

Furthermore, restarting the protein p53 additionally prevents fuel genertion for cancer. When p53 is returned, it prevents the expression and actions of GLUT1 and GLUT4 transporters (glucose gates“) in the cells. (Ref.)

3) Revival of the p53 gene. This work process is yet comparatively controversial, and additional studies must be performed to show fenbendazole triggers this action. (Ref.)

Nevertheless, there’s an escalating amount of research which have confirmed the reality that fenbendazole may actually boost the strongest tumor suppresser in the human body – p53. (Ref.)

It’s understood that an elephant has twenty copies of the p53 gene in its genome but people only have a single copy. Curiously, that’s why an elephant develops cancer less often than people. In spite of these animals being large in size, a bigger number of cells as well as a larger amount of possible genetic mutations.

Related:   Can Selenium Prevent Prostate Cancer

4) Cancer cells do not create a chemo-opposition to fenbendazole. What is fascinating, cancer cells can’s escape this de-wormer medication and adjust to its existence. Regrettably, this occurs in many more chemotherapy and biological therapy drugs.

The key process of chemoresistance is whenever cancer cells adjust to being able to expel the medications from themselves through unique drug efflux pumps known as P-glycoproteins. Fenbendazole isn’t a target for p-glycoproteins, therefore it can’t be expelled from cancer cells when it gets in them.

Consequently, the tumors do not create any opposition against fenbendazole, it still stays efficient and will still destroy cancer cells, not like paclitaxel, vinblastine, docetaxel, vincristine or additional kinds of chemotherapies. (Ref.)

As can be seen in the image below (Dogra 2018)

 

5) Fenbendazole can sensitize cancerous tumours to radiotherapy. It can sensitize cancerous tumours to radiotherapy in a comparable way similar to chemotherapy agents in the taxane group. [22].

***Fenbendazole functions like a moderate microtubule disrupting agent and brings on the death of cancer cells

**

Fenbendazole dose guide

Protocol (the initial version) – complimentary treatment of cancer

  • Fenbendazole 222 mg. Consume one capsule 3 days weekly, once time daily after eating a fatty dinner. * Then do not take any for 4 days. Replicate this cycle each week.
  • Vitamin E 800 U/I. Consume one capsule or another form once daily after eating without any waiting.
  • Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
  • CBD oil 25 milligrams. Consume one to two drops (total ~25 milligram) under your tongue daily before bedtime.

*- Fenbendazole is actually hydrophobic and it is not absorbed well by the bowels. Consuming this with food or after eating makes it absorb better.

Related:   The Do's and Don'ts of Earwax Management

Protocol (the altered, stronger version) – complimentary cancer treatment

  • Fenbendazole 222 milligrams. Consume one capsule daily after eating a fatty dinner without waiting. **
  • Vitamin E 800 U/I. Consume one capsule or some other version daily without waiting.
  • Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
  • CBD oil 25 milligrams. Consume one to two drops (total ~25 milligrams) under your tongue daily before bedtime.

** – Fenbendazole is virtually non-toxic to people without no liver or kidney failures.

Avoiding cancer relapse – prophylactic procedure

  • Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Replicate this cycle each week.
  • Vitamin E 800 U/I. Consume one capsule or some other version daily after eating without stopping.
  • Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after you eat breakfast and lunch without stopping.
  • CBD oil 25 milligrams. Consume one to two drops (a total of~25 milligrams) under your tongue daily prior to bedtime.
  • Tumour marker steady checks every few months, routine annual cancer imaging tests. If there’s not any cancer relapse after five years, reduce the test frequency.

Avoiding cancer for somebody who was always free of cancer – prophylactic procedure

  • Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Duplicate this for ten weeks. Halt for ten weeks. Then replicate the cycle once more.
  • Vitamin E 800 U/I. Consume one capsule or some other kind daily after eating without stopping.
  • Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after eating breakfast and lunch without stopping.
  • CBD oil 25 milligrams. Consume one to two drops (a total of ~25 milligrams) under your tongue daily prior to bedtime.

Safety of Fenbendazole and possible side effects

Centered on toxicology findings, benzimidazoles like Fenbendazole, Albendazole or appear to be safe medications.

Though, a medication with no side-effects doesn’t exist. Scientific information reports don’t show substantial adverse responses from consuming fenbendazole. Still, there are some anecdotal reports of possible toxicity:

  • As much as five percent of people may have stomach-aches or loose bowels if they consume large amounts of fenbendazole without a break.
  • People who have severe kidney or liver failure have decreased medication excretion levels, consequently, fenbendazole may build up and produce unforeseen side-effects. You should divide the doses based on your circumstances.
    The procedure was intended to maintain the liver in optimum health; hence the schedule should be three days on it, and four off is recommended.
  • When utilized in huge amounts for long timeframes without a break, fenbendazole powder may bring on asymptomatic liver enzyme increases because of the material being mostly metabolized inside the liver. This can be reversed with the assistance of a pause for two weeks.
Related:   Seven Healing Principles to Guide and Heal You Along Your Cancer Journey

The procedure was created to maintain the liver in optimum health, hence the schedule of a weekly cycle of three days taking it and four days not taking it is recommended.

Though, increasingly more folks are applying fenbendazole for a timeframe of five days taking it and two days not taking it.

To maintain the liver health ideal, we recommend you consume 250 milligram capsules of Milk Thistle or take 150 milligrams of Silymarin every day as a helpful supplement to maintain it in good shape.

Fenbendazole clinical trials and papers

Another section for scientific pre-clinical papers, as well as in vitro studies on anti-cancer methods, and clinical trials with cancer. Analyze the accessible facts of published studies’ info. A section for info hungry enthusiasts.

To find out more please visit our website: https://fenbenlab.com/

 

References

1) Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
https://www.nature.com/articles/s41598-018-30158-6

2) Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

3) Fenbendazole as a Potential Anticancer Drug.
http://ar.iiarjournals.org/content/33/2/355.full

4) The Anthelmintic Drug Mebendazole Induces Mitotic Arrest and Apoptosis by Depolymerizing Tubulin in Non-Small Cell Lung Cancer.
https://mct.aacrjournals.org/content/1/13/1201.long

5) Pilot study of albendazole in patients with advanced malignancy. Effect on serum tumor markers/high incidence of neutropenia.
https://www.ncbi.nlm.nih.gov/pubmed/11474247

6) Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis.
https://www.ncbi.nlm.nih.gov/pubmed/15565325

7) Benzimidazole as Novel Therapy for Hormone-Refractory Metastatic Prostate Cancer.
https://apps.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf

8) Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.
https://www.ncbi.nlm.nih.gov/pubmed/18667591

9) Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer.
https://link.springer.com/article/10.1007%2Fs00280-009-1157-8

10) Repurposing Drugs in Oncology (ReDO) — mebendazole as an anti-cancer agent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

11) Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
https://pdfs.semanticscholar.org/2b47/0bf133be75b36c09ebc8b17e70cea85fd9af.pdf

12) Chronic myelogenous leukemia in a great horned owl (Bubo virginianus)
https://www.ncbi.nlm.nih.gov/pubmed/19530405

13) Dogra, N. (2018, August 9). Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Scientific Reports. https://www.nature.com/articles/s41598-018-30158-6

14) Fenbendazole.org. (2019). Fenbendazole Dosage Guide And Calculator. Scientific Research. https://www.fenbendazole.org/fenbendazole-information/fenbendazole-dosage-guide/

Author
Teddi Marzofka

InnoVision Health Media reports on health content that is supported by our editorial advisory board and content published in our group of peer reviewed medical journals.

48 Comments on Things You Should Know About Fenbendazole

  1. My husband had a double lung transplant 4 years ago only rejection drugs he is taking is prograf & predizone has a little kidney problem not bad and white count little low healthy otherwise. Some meds cause cancer would this be safe for him to take in case he gets it

  2. Excellent article, most comprehensive and clear presentation I’ve seen on fenbendazole. Thanks! I am using it 10 wks/yr for prevention have referred your article to several friends bucking cancer.

    To those seeking advice on will it cure this or that cancer, that is beyond the scope of the authors of this article. Give it a try. With cancer, you throw everything you can at it. And good luck to you all.

  3. I have rectal cancer. Stage 2. My prognosis is good, but if I can avoid surgery I will try anything. My understanding is that the use of Fenbendazole caused cancer death and the disappearance of it in the body. No cancer means no reason to cut. Im going to try Fenbendazole and hope for the best! I will post my results for all to see. Wish me luck!

  4. Took 222mg of fenbendazole for two weeks and blood pressure went up.
    Could the drug have been the cause and if so how long would it take to go down after stopping the drug?
    have not taken it in 5 days.

    • Yes! It would anaolutely be helpful to use the advised protoçols that have worked for others and there are published papers on many studies to verify this fact.

  5. The problem is getting this stuff. Cancer doctors refuse to prescribe it saying infectious doctors will have to do it, infections doctors say nope, no can do because this is not standard practice since there is no infections from their standpoint. Neither of them is willing to prescribe off label, and this stuff is only available to doctors and labs…where can I get this? Chemotherapy and radiation did more harm than good, and now all they want to do is be on hospice for comfort…I don’t believe in comfort, I believe in life.

    • You should try on indiamart.com site, I just bought 2 boxes of fenbendazole, every box has 10×10 pils, with 2 $ for 10 pills. With 40 $ plus delivery to your country, you solve the problem. You don’t need prescription!

    • You can purchase it from Amazon. I just did so. I have allergies to red meat and therefore can’t take anything in a gelatin capsule. I found that the company I ordered from provides it in a non-gelatin (a cellulose capsule) capsule of 222mgs. It has not yet arrived and it seems it will take a few weeks before it will, but the cost is minimal (45.00 +/-) with free shipping. It is called Phenbenzadole from Ist Wellness company. I am having difficulty finding curcumin 600mgs at a fair price. Anyone have a recommendation for me?

    • It doesn’t need a script. You can find the powder on Amazon. Or at any livestock supply store in paste or liquid form.

  6. Fenben and new leaf pure CBD stopped my brothers seizures and arrested the development of large late stage 4 brain tumor and prolonged life and quality of life greatly. Still fighting months beyond expiration date stated by doctors. We have been so blessed with these months together.

  7. Pancure Fenbendazole: 25 gram tubes, 2-3 grams applied through skin and a small oral dose everyday, 30MG CBD AM Pm . E. D. B. Good fortune, life is eternal this i swear.

  8. I was given a 3 month prognosis for Glioblastoma brain tumour. Eat once a day fast for 22 hours meditate exercise, clean water no sugar. Have you heard of the golden protocol? PS this was 6 years ago. email me and i will send it to you if you like

  9. I was diagnosed with stage 3 prostate cancer…With the blessing of my doctor i began the above therapy and after 3 months with no side effects I had an MRI scan…they could not find any carcinoma it had GONE !!I feel very blessed to have found this website……Thankyou all

  10. I AM A 65 YEAR OLD WOMAN WHO HAS BEEN HEARING ALOT ABOUT THIS THERAPY. I RECENTLY HAD A COLON GUARD HOME TEST COME BACK POSITIVE. THOUGH THIS DOES NOT IMPLY THAT I HAVE CANCER, A COLONOSCOPY IS NEXT. MAYBE. I WOULD JUST RATHER TAKE FENBENDAZOLE NOW AND SEE WHAT TRANSPIRES. I WAS WONDERING IF IT CAN BE TAKEN ALONE. NO OTHER SUPLIMENTS? I AM SO THANKFUL FOR FINDING THIS SITE AND ARTICAL. GOD SPEED!!!!

  11. I WOULD LIKE TO SHARE SOMETHING WITH YOU. IN FEB OF THIS YEAR MY DR RECOMMENED A CT SCAN OF MY LUNGS AS I AM A SMOKER OF 40YRS PLUS. THE SCAN REVEALED 2 NODULES IN MY RIGHT LUNG. HE SAID THAT WE WOULD WAIT 3 MONYHS AND RESCAN TO SEE IF THERE ARE CHANGES. I ASKED HIM IF WE COULD ORDER A PT SCAN NOW. HE ARRANGED IT THROUGH MY INSURANCE, BUT I HAD A 3 WEEK WAIT.SO SINCE I HAD BEEN CHECKING OUT FENBEN, I DECIDED TO DO A REGIMENT FOR THE 3 WKS IN BETWEEN. SO I JUST GOT THE CALL FROM MY DRS OFFICE TODAY OF THE RESULTS. IT WAS NEGATIVE, CLEAR. EVEN THOUGH I HAD NO BIOPSY TO KNOW WEATHER IT WAS CANCER OR NOT, IT REALLY DOESNT MATTER TO ME. BECAUSE ITS NOW GONE. AND I 100% BELIEVE IT WAS DUE TO FENBEN. I CANT THANK YOU ALL FOR YOUR TESTIMONIALS AND TRUTHS ON THIS DRUG. MY ONLY REGRET IS THAT I DIDNT KNOW THIS WHEN MY PARENTS WERE DYING FROM CANCER. GOD BE WITH YOU ALL!

    • Wonderful!Thanks.You really inspire me with your results.My surgeon was warning me that some cancer still remained in me rectum,that it has to go,the only way is surgery,removal of the rectum,closing the anus,carry a bag for the rest of my life!!.I am male 92 yrs.Thanks a million for sharing your story.

  12. Dr. Elizabeth Eads made these recommendations to me For someone I know who is diagnosed with cancer a few weeks ago(A few other suggestions are added as well):
    Fenbendazole 444 mg twice a day (panacur on Amazon)
    For 4 weeks
    C60 daily or Turmeric 1000 mg daily (an FNP told me to add ginger to this which you can get in capsule for him to protect against liver damage from turmeric)
    Berberine 500 mg twice a day
    Selenium 100 mg daily
    B17 500 mg twice a day (rawfoodandvitamins.com)
    Emerald (CBD/mct)- 1 dropper daily HHW store
    Humic/fulvic- 1 capful twice a day HHW store
    Wavwatch-set on detox frequency 12 hours a day (could also split up 6 hours on detox 6 hours on the organ of your choice depending on what’s affected) wavwatch.com

    The family member of mine noted a 50% decrease in tumor size on repeat imaging after only 4 days on this protocol

    Safespaceprotection.com
    (See eye aye uses this company)

    Dr. Schultz superfood 100 tabs

    Peak pure and natural “peak maximum endurance” capsules

  13. Look up Joe Tippins’ protocol

    Also Dr. Eads advised my family member to take ivermectin (allegedly it breaks down the spike protein And also has anti-cancer properties of its own)

    Also look up the book, World Without Cancer The story of vitamin B-17

  14. Are you supposed to take the vitamin E, Curcumin, and CBD for 7 days a week? Or just the 3 days you take the fenbendazole?

  15. BACK AT YOU AGAIN. I JUST WANTED TO SHARE WITH READERS THAT THE REGIMENT I TOOK. I DISSOLVED ONE 222MG OF SAFE GUARD FENBEN INTO ONE TABLESPOON OF EXTRA VIRGIN OLIVE OIL AND DRANK IT. NOT REAL GOODY TASTING BUT DOABLE. TOOK IT 3 DAYS ON 4DAYS OFF. I ATE A FATTY MEAL AND TOOK THE OIL MIX IMMEDIATLY AFTER MY MEAL. I DID NOT USE ANY OF THE OTHER RECOMMENDED STUFF. AND IT DID THE TRICK FOR ME. BUT THAT IS MY OPINION ON DOSING. I STOPPED AFTER A 3 WEEK DOSE AND AM ABOUT TO BEGIN ANOTHER ROUND. GOD BLESS ALL WHO SHED THIS LIGHT ON US.

  16. I need this in my life SCC cancer 3 neck dissection last one the 15th of April I’d like to have the protocol due to I have been thru radiation twice and chemo once and keep having reoccurrence . Thank you

  17. I was diagnosed with Stage 4 Ovarian Cancer about a year and a half ago. I went through 6 rounds of chemo and surgery. A CT-Scan showed all but a small mass was killed but doctors were not sure if it was cancerous. All my labs were very good. Six months ago, after another CT-Scan, the mass had begun to grow so I just completed another three rounds of chemo. A CT-Scan shows the mass has decrease in size about 40% so my doctor has scheduled another three rounds of chemo. My question is: Would be OK to take the fenbendazole while going through chemo treatments?

Leave a Reply

Your email address will not be published.


*